All The Latest Fucoidan Research

We’re Committed To Evidence-Based Outcomes.

There is a significant body of emerging fucoidan research that is growing every day.

Over 1500 independent, peer-reviewed scientific studies are available on the bioactive properties of fucoidan. These research papers have focused on key health topics including, immunity support, heart and digestive health, anti-inflammation, and anti-cancer activity. This large body of comprehensive fucoidan research has mainly been conducted via in vitro studies (human cells in the laboratory), animals studies and, more recently, human clinical trials.

Substantiation of the health benefits of fucoidan is constantly changing and we are continually reviewing and sorting through new research. We have included the latest, most relevant, research below. Please let us know if you have a study you think we should take a look at.

Our goal is to present information to guide you and give you the tools to understand how fucoidan might affect YOUR body. For our comprehensive summary of the health benefits of fucoidan, make sure you read this page. Please also note that our fucoidan products are not intended to diagnose, treat, cure or prevent any disease.

REFERENCES

Supplementation of Elderly Japanese Men and Women with Fucoidan from Seaweed Increases Immune Responses to Seasonal Influenza Vaccination.
Hirokuni Negishi, Mari Mori, Hideki Mori, Yukio Yamori. The Journal of Nutrition, 2013

A Combined Phase I and II Open-Label Study on the Immunomodulatory Effects of Seaweed Extract Nutrient Complex.
Myers SP, O’Connor J, Fitton JH, Brooks L, Rolfe M, Connellan P, Wohlmuth H, Cheras PA, Morris C. Biologics, 2011

Suppressive Effect of Dietary Fucoidan on Proinflammatory Immune Response and MMP-1 Expression in UVB-Irradiated Mouse Skin.
Maruyama H, Tamauchi H, Kawakami F, Yoshinaga K, Nakano T. Planta Med, 2015

Fucoidan From Macrocystis Pyrifera Has Powerful Immune-Modulatory Effects Compared To Three Other Fucoidans.
Zhang W, Oda T, Yu Q, Jin JO. Mar Drugs, 2015

Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses.
JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q.  PLoS One. 2014

Evaluation of adjuvant effects of fucoidane from brown seaweed Fucus evanescens and its structural analogues for the strengthening vaccines effectiveness.
Kuznetsova TA, Ivanushko LA, Persiyanova EV, Shutikova AL, Ermakova SP, Khotimchenko MY, Besednova NN. Biomed Khim. 2017

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

Antiviral activity of Undaria pinnatifida against herpes simplex virus.
Thompson KD1, Dragar C. Phytother Res. 2004

Studies on evaluation of natural products for antiviral effects and their applications.
Hayashi T. Yakugaku Zasshi. 2008

Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection.
Hayashi K, Nakano T, Hashimoto M, Kanekiyo K, Hayashi T. Int Immunopharmacol. 2008

Antiviral activity of sulfated polysaccharide from the brown algae Laminaria japonica against avian influenza A (H5N1) virus infection in the cultured cells.
Makarenkova ID, Deriabin PG, L’vov DK, Zviagintseva TN, Besednova NN. Vopr Virusol. 2010

Mekabu fucoidan: structural complexity and defensive effects against avian influenza A viruses.
Synytsya A, Bleha R, Synytsya A, Pohl R, Hayashi K, Yoshinaga K, Nakano T, Hayashi T. Carbohydr Polym. 2014

Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus
Karla Morán-Santibañez, Lucia Elizabeth Cruz-Suárez, Denis Ricque-Marie, Daniel Robledo, Yolanda Freile-Pelegrín, Mario A. Peña-Hernández, Cristina Rodríguez-Padilla, and Laura M. Trejo-Avila. BioMed Research International. 2016

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis.
Myers SP, O’Connor J, Fitton JH, Brooks L, Rolfe M, Connellan P, Wohlmuth H, Cheras PA, Morris C. Biologics. 2010

Fucoidan Extracts Ameliorate Acute Colitis.
Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N. PLoS One. 2015

Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells.
Lim JD, Lee SR, Kim T, Jang SA, Kang SC, Koo HJ, Sohn E, Bak JP, Namkoong S, Kim HK, Song IS, Kim N, Sohn EH, Han J. Mar Drugs. 2015

Fucoidan Prevents the Progression of Osteoarthritis in Rats.
Lee DG, Park SY, Chung WS, Park JH, Hwang E, Mavlonov GT, Kim IH, Kim KY, Yi TH. J Med Food. 2015

In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2.
Dewi L. Med Arch. 2016

Effect of fucoidan on aspirin-induced stomach ulceration in rats.
Choi JI, Raghavendran HR, Sung NY, Kim JH, Chun BS, Ahn DH, Choi HS, Kang KW, Lee JW. Chem Biol Interact. 2010

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae
Helen Fitton, Giorgio Dell’Acqua, Vicki-Anne Gardiner , Samuel S. Karpiniec , Damien N. Stringer and Emma Davis. Cosmetics 2015,

Low-molecular-weight fucoidan inhibits the viability and invasiveness and triggers apoptosis in IL-1beta-treated human rheumatoid arthritis fibroblast synoviocytes.
Shu Z, Shi X, Nie D, Guan B. Inflammation. 2015

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro.
Chua EG, Verbrugghe P, Perkins TT, Tay CY. Evid Based Complement Alternat Med. 2015

Fucoidan Extracts Ameliorate Acute Colitis.
Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N. PLoS One. 2015

Effect of fucoidan on aspirin-induced stomach ulceration in rats.
Choi JI, Raghavendran HR, Sung NY, Kim JH, Chun BS, Ahn DH, Choi HS, Kang KW, Lee JW. Chem Biol Interact. 2010

Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae.
Shang Q, Shan X, Cai C, Hao J, Li G, Yu G. Food Funct. 2016

Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1.
Iraha A, Chinen H, Hokama A, et al. World J Gastroenterol. 2013

Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells.
Matsumoto S, Nagaoka M, Hara T, Kimura-Takagi I, Mistuyama K, Ueyama S. Clin Exp Immunol. 2004

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

The sulfated polysaccharide fucoidan rescues senescence of endothelial colony-forming cells for ischemic repair.
Lee JH, Lee SH, Choi SH, Asahara T, Kwon SM. Stem Cells. 2015

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae.
Helen Fitton, Giorgio Dell’Acqua, Vicki-Anne Gardiner, Samuel S. Karpiniec, Damien N. Stringer and Emma Davis. Cosmetics. 2015

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus.
Minna K. Rahnasto-Rilla, Padraig McLoughlin, Tomasz Kulikowicz, Maire Doyle, Vilhelm A. Bohr, Maija Lahtela-Kakkonen, Luigi Ferrucci, Maria Hayes, and Ruin Moaddel. Mar Drugs. 2017

The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines.
Min EY, Kim IH, Lee J, Kim EY, Choi YH, Nam TJ. Int J Oncol. 2014

Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3.
Wang T, Zhu M, He ZZ. Cell Mol Neurobiol. 2016

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial.
Hsiang-Lin Tsai, Chi-Jung Tai, Ching-Wen Huang, Fang-Rong Chang and Jaw-Yuan Wang. Marine Drugs 2017

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer.
MASAHIDE IKEGUCHI, MANABU YAMAMOTO, YOSUKE ARAI, YOSHIHIKO MAETA, KEIGO ASHIDA,KUNIYUKI KATANO, YASUNARI MIKI, and TAKAYUKI KIMURA. Oncol Lett. 2011

Therapies from Fucoidan: An Update.
Janet Helen Fitton, Damien N. Stringer, and Samuel S. Karpiniec. Mar Drugs. 2015

Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses.
Jin JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q. PLoS One. 2014

The anticancer effect of fucoidan in PC-3 prostate cancer cells.
Boo HJ, Hong JY, Kim SC, Kang JI, Kim MK, Kim EJ, Hyun JW, Koh YS, Yoo ES, Kwon JM, Kang HK. Mar Drugs. 2013

Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation.
Yamasaki Y, Yamasaki M, Tachibana H, Yamada K. Biosci Biotechnol Biochem. 2012

Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells.
Zhang Z, Teruya K, Yoshida T, Eto H, Shirahata S. Mar Drugs. 2013

Fucoidans Stimulate Immune Reaction and Suppress Cancer Growth.
Vetvicka V, Vetvickova J. Anticancer Res. 2017

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan.
Zhang Z, Till S, Jiang C, Knappe S, Reutterer S, Scheiflinger F, Szabo CM, Dockal M. Thromb Haemost. 2014

Sea, carbohydrates and clotting: a triad on the road of drug discovery.
Pomin VH. Mini Rev Med Chem. 2014

Anticoagulant activity of fucoidans from brown algae.
Ushakova NA, Morozevich GE, Ustiuzhanina NE, Bilan MI, Usov AI, Nifant’ev NE, Preobrazhenskaia ME. Biomed Khim. 2008

Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica.
Zhao X, Guo F, Hu J, Zhang L, Xue C, Zhang Z, Li B. Thromb Res. 2016

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.
REFERENCES

Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults.
Hernández-Corona DM, Martínez-Abundis E, González-Ortiz M. J Med Food. 2014

Could dietary seaweed reverse the metabolic syndrome?
Teas J, Baldeon ME, Chiriboga DE, Davis JR, Sarries AJ, Braverman LE. Asia Pac J Clin Nutr. 2009

Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice.
QingsenShang, GuanruiSong, MeifangZhang, JingjingShi, CuiyingXu, JiejieHao, GuoyunLi, GuangliYu. Journal of Functional Foods. 2017

Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation.
Park J, Yeom M, Hahm DH. J Pharmacol Sci. 2016

This referenced scientific information is for informational use only. We do not claim that any results reported will occur in our customers. This information should not be read to recommend or endorse any specific products.

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2018-05-15T21:23:04+00:00